Compartmentalization of spermine and spermidine in the herpes simplex virion.
نویسندگان
چکیده
Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1.6 +/- 0.2. The spermine present within the nucleocapsid is sufficient to neutralize at least 40% of the viral DNA. Disruption of the envelope with nonionic detergent and urea resulted in the selective loss of spermidine. Exogenous ornithine can function as a precursor to host and viral polyamines only before infection.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 68 11 شماره
صفحات -
تاریخ انتشار 1971